You’ve seen the drug work wonders for others. But it hasn’t had the same effect on you. Luckily, Trucility isn’t the only option available. We discuss and compare Trulicity alternatives such as Ozempic, Mounjaro, Saxenda and more to help you find your perfect fit.
What is Trulicity?
Touted as a weight management aid, Trulicity (dulaglutide) was initially prescribed to help control blood sugar levels in individuals with Type 2 Diabetes. It belongs to the class of drugs GLP-1 agonists, which you’ll see mentioned throughout this article. In addition, it is often prescribed to reduce the risk of certain cardiovascular complications in people with heart disease. As with any medication, there are side effects involved. Digestive issues such as nausea, vomiting, diarrhea, and constipation are some of the main aftereffects to be expected.
It should be highlighted that Trulicity is not intended for weight-loss use. Those who are not diabetic should not use this drug. Instead, they should research alternatives specifically designed to treat obesity such as gastric balloons or other bariatric procedures.
However, if you don’t think it’s the right fit for you, there’s no need to worry. There are many alternatives to Trulicity available in today’s market!
5 Alternatives to Trulicity
As with any medication, weighing the positives and negatives is essential. If you aren’t certain what it is you’re looking for, we’ve compiled a list of popular substitutes. Many of these options are drugs used to lower A1C and boost weight loss making them effective insulin-resistant medications for weight loss.
Semaglutide (Ozempic, Rybelsus, Weglovy)
Semaglutide is marketed under the brand names Ozempic, Ryblesus and Weglovy. As another GLPL-1, it leads to a decrease in glucose production, making you feel fuller for longer by slowing down stomach emptying. Semglutide also promotes an increase in insulin levels while reducing the risk of events like stroke or heart attack.
Though they contain the same active ingredient, each brand carries slight variations. Ozempic and Wegovy are both given as a subcutaneous injection (just below the skin) whereas Ryblesus comes in tablet form. Another difference is the dosage amount and strength of each option.
Ozempic has gained credibility as the go-to weight-loss solution, however, it is worth bearing in mind that it has not been industry-approved for this purpose. While it can produce results, it’s worth considering the potential costs. Many are not aware of the post-treatment symptoms and what happens to your body when you stop taking Ozempic. If you are seeking Semaglutide alternatives or drugs like Trulicity, Wegovy or Rybelsus may be worth exploring.
Wegovy is FDA-approved and is used in conjunction with a diet plan and exercise. It encourages an overall lifestyle and habit adjustment rather than a quick fix. For those looking for a Trulicity equivalent, these medications might be worth considering
Finally, Rybelsus is an oral tablet that slows the rate of digestion. It is recommended to take it first thing in the morning on an empty stomach and before any other medications, as some of the Rybelsus side effects include nausea and vomiting. FDA approval has not been granted yet.
Liraglutide (Victoza, Saxenda)
Vitctoza and Saxenda both contain the active ingredient Liraglutide.
Victoza has the dual purpose of glycemic control and the reduction of cardiovascular issues. It is also a GLP-1 agonist that has to be injected daily. In contrast, Saxenda has been FDA-approved for weight loss in the case of overweight or obese individuals. It helps slow down gastric emptying, increasing the sensation of satiety. However, Saxenda cannot be taken with Victoza or Trulicity.
But just how effective are these anti-obesity drugs? In terms of overall success rate, Saxenda was awarded a 7.5/10 while Trulicity tallied a lower score of 5.2/10.
Tirzepatide (Mounjaro)
Tirezepatide (Mounjaro) is another FDA-approved medication that is regularly prescribed to patients with type 2 diabetes. It is used for glucose-level management and has shown promising potential for weight-loss management. What separates Mounjaro from other drugs are its dual agonist properties. It stimulates both the GLP-1 and GIP receptors: it mimics the naturally present hormone and reduces gastric emptying while inducing more insulin secretion. Though it is relatively new in the market, it has shown a promising ability to lower AC1 levels while supporting weight loss. The weekly dose is administered by injection so it may not be a viable option for you if you’re squeamish of needles.
Metformin (Glucophage, Glumetza, Riomet)
Like many of the drugs on this list, the main role of Metformin is to control blood sugar levels in patients with type 2 diabetes mellitus. The three known brands are Glucophage, Glumetz and Riomet, each promising similar levels of effectiveness. Metformin reduces the amount of glucose absorbed and produced while increasing insulin sensitivity, making it a viable Trulicity generic alternative. Additionally, Metformin is recognized as a cheaper and cost-effective substitute for Trulicity.
Given its long-standing status for glycemic control, Metformin is often prescribed to newly diagnosed individuals. However, it may be used in combination with Trulicity or other medications if it isn’t effective enough on its own.
For needle-weary people, the drug is administered orally. Truclicity is injected weekly while Metformin is taken in tablet-format daily.
Enexatide (Byetta, Bydureon Bcis)
Enexatide is another injectable GLP-1 and works to improve blood sugar levels by stimulating insulin release after eating, slowing the rate of digestion and preventing stored sugars from being released by the liver.
Byetta should be injected twice daily before morning and evening meals. Bydureon Bcis only require one weekly shot on the other hand. In a study carried out by Eli Lilly, results showed that 49.4% of Enexatide users were likely to discontinue usage. While it is a possible alternative, the statistics implied that Trulicity has better adherence, longer persistence and lower discontinuation rates compared to Byetta. In the long run, people may find Trulicity an easier or more impactful drug, leading to better outcomes.
But, each to their own! (Or each to what your healthcare professional advises, rather.)
Natural Alternatives to Trulicit
If you’re not the biggest fan of daily or weekly injections, there’s no need to worry. There are a few natural alternatives available to increase GLP-1 levels without getting poked or prodded.
While they may not be as potent as what’s provided by pharmacists, they can play a substantial role in managing weight and helping embrace a lifestyle change. However, those with diabetes 2 should be medicated and following treatment.
- Dietary Changes: High-fibre foods naturally trigger GLP-1 and slow down digestion. Nuts, grains and vegetables such as broccoli and carrots have been shown to impact glycemic levels positively. Natural fat burners such as ginseng, turmeric and ginger can also provide viable results.
- Get Moving: One of the age-old solutions is exercise. While the science isn’t exact, exercise and GLP-1 both help improve insulin function and promote weight loss. Moderate-intensity exercise such as swimming, walking or cycling can yield significant benefits. As well as giving you an excuse to get out of the house or listen to your favorite podcast, they will also contribute positively to how insulin affects your weight.
Trulicity Alternatives Compared: Which One Suits You?
While it has proven to be an effective and life-changing solution for many, there are many Trulicity options available. Whether you’re thinking of opting for Ozempic or leaning towards Liraglutide, it’s important to discuss any potential change with your healthcare provider.
The alternatives that we have mentioned have not been developed for weight loss, nor should they be taken by non-diabetic patients. We strongly recommend approved and specifically designed obesity treatments, such as non-surgical gastric balloons.
Each weight-loss journey is different. Taking a bit of extra time to weigh up the pros and cons of a gastric balloon will save you hassle and disappointment further along your treatment.
